The game is divided into 12 chapters, in each of which the hero has to fight enemies and solve puzzles.

Arrival
After landing on Ishimura, you must find the command center. You must activate the elevator controls and run down the corridor to it. In the room find the broken door and, by shooting the terminal next to it, open it. Behind it there will already be a monster waiting, so it’s better to be ready.

In the next room you can listen to the conversation between the two surviving crew members. To get to them, you will have to fix the wagon. You will have to walk down the corridor again to the great hall. Here you will have to repel the attack of the enemies. It is necessary to start first the near, then the far piston, go to the control panel and start it. Then in the technical compartment to pick up the key and return to the big hall. After starting the computer it is necessary to repel a large attack of necromorphs, then you can go to the platform with the wagon.

After repulsing the attack Isaac has to find the components for the bomb. When everything is collected, the hero will meet the first boss of the game – a creature that turned into the captain of the ship. After defeating it the player must return to the wagon and go to the engines of Ishimura.

Orbital Correction.
To get through this chapter, it is important to restart the fuel supply to the engines. It is necessary to reach the gravity shields and turn on two consoles. After the first one, use the kinesis to pull up the bridge and move to the next one. Then go back and turn on the turbine. To do this, you will have to repel a wave of attacks, and then activate the turbine with the pistons. The only thing left to do is to start Ishimura and at the same time fight off the necromorphs. Then you have to get back to the wagon and move to the ship’s captain’s bridge.

Death is inevitable.
Ishimura flies through a cluster of meteorites, so she occasionally shakes. We must quickly make a run for the captain’s cabin. Here Hammond brings Isaac up to speed. The hero goes to the main hall, where he meets the mini-boss.

After winning, the hero turns on the elevators and descends to the lower compartments. Here he will meet an unusual room in which he has to navigate the slabs without hitting the illuminated areas. In the next room he has to fight another Brutus and redirect energy to the main guns. In the lower bays through open space you have to get to the computer and start the life support system of the turrets.

Lethal Addiction.
The mission is to find out what caused the poison gas. The hero runs to the medical bay. Kendra says he needs to get mutant DNA. In one of the rooms Isaac meets a mad doctor who is trying to create flawless creatures. He has to fight one of his creations.

In the madman’s office, the hero takes the DNA sample. But the doctor releases all the oxygen into space, so he has to quickly run to the lab and create the poison. After that, Isaac has one last fight with the creatures of the madman. When they are done, you have to go back to the wagon.

Dangerous Impurities.
Hammond is given the task of destroying all mutants. In the west greenhouse to begin this mission and at the same time with the help of the computer to replace the feeding tank. It is necessary to activate the elevator and go higher. At the same time the player must kill all releasing poison creatures. In the last room to endure a battle with Leviathan. To destroy it the player should shoot at the tentacles. After victory it is necessary to return to the wagon.

Step into the void
Here you have to signal the rescue ship. You can do this by attaching a beacon to the asteroid and launching it into space. Isaac has to run to the central hall of the compartment and take the elevator down. On level B the hero activates the remote control and goes to the floor control center. Here there is a corpse, from which you need to get the key, and then go down to the elevator on level D.

From the elevator Isaac needs to run on to the moving platform that will help him get to the opposite side. Here the hero will have an assistant, who will open the door further. In the room you should take the beacon and go up to the level C. Next you need to go up another elevator, but it has a broken battery. Another one can be found on the opposite side of the compartment.

From the elevator the hero enters a huge room with an asteroid in the middle. It is necessary to fix a beacon on it and destroy the gravity locks. Then take the batteries from the elevator and move it to the next one. Having risen, the hero finds himself in front of a closed door, but with the help of a card he will open it. Inside will be the asteroid launcher. Now it remains to wait for the help signal to be heard and return to the wagon.

Find and Rescue
You’ll have to fix the signal remote. From the captain’s bridge you have to take the elevator up and go on to the big antenna. To fix it, you have to make sure that all the working parts of the antenna are in the front row.